Start Of Prolarix� Phase 2 Study In Liver Cancer

� Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on decisive care and cancer, announces the knowledgeableness of a phase 2a proof-of-concept study of Prolarix�, a targeted prodrug chemotherapy being highly-developed for the treatment of primary liver cancer (hepatocellular carcinoma or "HCC"). This follows promising data from a phase 1 study of Prolarix, presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, USA on 2 June 2008.


HCC is the sixth most vulgar cause of cancer in the world1 and despite the recent approval of sorafenib (Nexavar�, Onyx/Bayer), a new chemotherapy which is being adoptive as the standard of care for HCC, life expectancy remains less than 12 months from diagnosis. Moreover, less than 20% of patients survive beyond one year, and less than 5% survive beyond five eld.


The phase 2a proof-of-concept study is designed to evaluate neoplasm response in addition to safety and tolerability of Prolarix in 14 patients with non-resectable HCC world Health Organization have not been treated with sorafenib. The report has been initiated at a situation in Belgium and extra study sites in East Asia have been identified for inclusion in the study. The results of the sketch are expected in the second half of 2009.


Andrew Heath, Chief Executive of Protherics commented:


"Scientifically acclaimed, Prolarix offers renewed hope for the many patients with primary liver cancer for whom there are very few treatment options. If the results from this study are positive, a licensing partner will be sought for Asia where the incidence of this type of cancer is highest."


1 Parkin DM, Bray F, Ferlay J, Pisani P. Global malignant neoplastic disease statistics, 2002 CA Cancer J Clin. 2005;55;74-108


About Protherics


Protherics (LSE: PTI, NASDAQ: PTIL) is a leading external biopharmaceutical company focused on specialist products for critical care and cancer.



The Company has deuce critical concern products, CroFab� and DigiFab�, approved for sale in the US. The Company has the opportunity to sell these products in the US from October 2010 together with Voraxaze�, a supportive cancer care product, next anticipated commendation in the US in 2010. Protherics is besides developing a number of other products in the cancer arena that it can market in-house.


In addition, Protherics has various potential smash hit products that require development and commercialization partners. These include CytoFab� which has been partnered by AstraZeneca in a major licensing deal, and also Angiotensin Therapeutic Vaccine and Digoxin Immune Fabs for which licensing partners will be sought in 2008-2009. These products receive the voltage to be high value products that can provide additional financing for the Company.


Protherics reported revenues of �26.1 jillion for the year over 31 March 2008 and a stiff cash balance of �37.7 zillion. With headquarters in London, the Company has approximately 300 employees across its operations in the UK, US and Australia.

About Prolarix�


Prolarix is a targeted chemotherapy existence developed for the handling of chief liver cancer the Crab (hepatocellular carcinomas, HCC) and other choice tumours. Prolarix is a combination therapy of two low molecular weight compounds, a prodrug* (called tretazicar; previously CB1954) and an enzyme co-substrate* (called caricotamide; previously EP-0152R). The prodrug tretazicar toilet be activated by an endogenous enzyme called NQO2, to a highly responsive, short-lived cytotoxic agent which causes a high degree of DNA cross-linking. The NQO2 enzyme is latent and hence inactive in body tissue, but Protherics' scientists get discovered that the enzyme is active in the presence of a co-substrate called caricotamide. The NQO2 enzyme is absent or in low levels in many normal body tissues, including bone marrow, but its natural action is increased in sealed tumour types (particularly hepatocellular carcinomas). The coadministration of the prodrug tretazicar and the cosubstrate caricotamide is therefore expected to event in the enhanced activation of the prodrug in the quarry tumour cells, resulting in their death whilst minimising harm to healthy, non-cancerous cells.

Glossary


Prodrug* - A compound that is converted within the body into its fighting form and that has no therapeutical effects of its possess. A prodrug is useful when the active drug may be too toxic to administrate systemically, the active dose is captive poorly by the digestive tract, or the organic structure breaks down the active drug ahead it reaches its mark.


Co-substrate* - A speck that interacts with an enzyme and is compulsory for its activity.


Cytotoxic* - A chemical which has a direct toxic effect to cells, causation their expiry.


Tretazicar* is 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954), an antitumour prodrug

Caricotamide* is

Detroit Area Catholic Leaders Focus On Document Condemning Contraception

�Despite "overpoweringly negative" responses and "rampant noncompliance" of some Roman Catholics to Pope Paul VI's 1968 Humanae Vitae, which condemns contraception use, some Catholic leaders in the Detroit area are increasingly promoting the encyclical letter, the Detroit News reports. Some priests in the area said church members are expressing a growing interest in the document's teachings (Krupa, Detroit News, 8/20). "Humanae Vitae," which translates to "On Human Life," is a written document that says most Catholics should refrain from victimisation "artificial giving birth control" (Daily Women's Health Policy Report, 5/12).

A conference on Humanae Vitae is scheduled for adjacent month at Sacred Heart Major Seminary in Detroit. Janet Smith, a professor at the seminary, aforesaid, "Our intent is to deepen the understanding of the commandment, so that it testament be recognized by Catholics, and to make them better defenders of it." She added that the seminary besides is "trying to meet those world Health Organization have rejected it to reconsider and hopefully to accept it."

Some surveys have shown that more than 90% of sexually alive Catholic women have used some form of nascency control, and about the same pct of Catholics believe the church should permit members to role condoms and oral contraceptive method. However, Robert McClory, chancellor of the Archdiocese of Detroit, aforementioned the jr. generations "non involved with the intensiveness of the introduction of Humanae Vitae" view the document as a "new approach" to sexuality. He said that the topic most often is raised in marriage preparation courses, adding that some young couples are beginning to show a willingness to follow the encyclical (Detroit News, 8/20).


Reprinted with kind permission from hTTP://www.nationalpartnership.org. You can persuasion the entire Daily Women's Health Policy Report, search the archives, or sign up for email speech here. The Daily Women's Health Policy Report is a unblock service of the National Partnership for Women & Families, published by The Advisory Board Company.


� 2008 The Advisory Board Company. All rights reserved.



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Heart tests for Scottish athletes

Scotland's first cardiac screening programme for young athletes has been opened at Hampden Park in Glasgow.

The �200,000 pilot project will use ECG and ultrasound screening to test for susceptibility to Sudden Cardiac Death.

Screening will be offered to athletes over the age of 16 who take part in any organised amateur sports.

Calls for such a programme were made following the death from heart failure of Motherwell FC captain Phil O'Donnell, 35, in December.

The screening service, at Hampden's Sports Medicine Centre, will be offered to the Scottish Institute for Sport, regional institutes of sport and sport governing bodies.

Up to 4,000 people a year are expected to take part.

The screening will combine questionnaires and testing to identify those at risk of Sudden Cardiac Death (SCD).

Anyone found to be at greater risk of SCD will be referred to a specialist for further investigation or treatment.

The programme is a collaboration between the Scottish Government, the Scottish Football Association (SFA) and the University of Glasgow.

Scottish Health Secretary Nicola Sturgeon said: "Although SCD is very rare, it robs us of seemingly healthy young people with their whole lives ahead of them. The loss of each of these lives is a tragedy.

"Many professional athletes can be screened by their sporting bodies, indeed, professional footballers in the SPL already have checks every year.

'Preventable deaths'

"But until now there has been no opportunity for young Scots who participate in organised amateur sports to have access to appropriate testing.

"The launch today of this pilot means that young Scots will soon be able to take part in sport with a greater degree of safety than in the past and help avoid the tragedy of further preventable deaths."

The pilot project was welcomed by Wilma Gunn, 63, from Selkirk in the Scottish Borders, whose son Cameron died in 1991, the day before his 20th birthday.

She later set up Scottish HART, a charity to raise funds for screening for all young athletes.

"It's a big step forward to get a pilot scheme," she said.

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Mexican Officials Promote Sex Education Among Young People

�
Mexican officials on Wednesday announced their intention to promote turn on education among young

Ween

   
Artist: Ween

   Genre(s): 
Rock
   

---

Discography:


   
 La Cucaracha

   Year: 2007   
Tracks: 13


   
 Friends Ep

   Year: 2007   
Tracks: 5


   
 White Pepper

   Year: 2000   
Tracks: 12


   
 Paintin' The Town Brown (cd2)

   Year: 1999   
Tracks: 3


   
 Paintin' The Town Brown (cd1)

   Year: 1999   
Tracks: 16


   
 The Mollusk

   Year: 1997   
Tracks: 14


   
 12 Golden Country Greats

   Year: 1996   
Tracks: 10


   
 Chocolate and Cheese

   Year: 1994   
Tracks: 16


   
 Pure Guava

   Year: 1992   
Tracks: 19


   
 The Pod

   Year: 1991   
Tracks: 23


   
 God Ween Satan-Anniversary Edition

   Year: 1990   
Tracks: 26


   
 The Live Brain Wedgie

   Year:    
Tracks: 11

---

Ween was the ultimate cosmic buffoon of the alternative stone epoch, a prodigiously talented and deliriously odd duette whose lick traveled far beyond the constraints of lampoon and knickknack into the heart of surrealist x. Despite a mastery for apparently every chromosomal mutation of the melodious spectrum, the group refused to play it full-strength; in effect, Ween was brattish deconstructionists, kicking malicious gossip on the pop humankind around them with unbalanced mirth. Along with the occasional frat-boy lapses into misogyny, racial discrimination, and homophobia, the band's razor-sharp caustic remark cut to the inherently lightheaded mettle of john Rock & roll with hilariously piercing savagery; fueled by psilocybin mushrooms and an all-consuming craving for hot meals, Ween created their possess poised population, a parallel dimension where the only hallowed cow was their possess demon immortal, the Boognish.


The duo formed in suburban New Hope, PA, in 1984, when 14-year-olds Mickey Melchiondo and Aaron Freeman adoptive their various fraternal aliases, Dean and Gene Ween, and cut the number 1 of literally thousands of dwelling house recordings. At about the like time Freeman -- working under the name Synthetic Socks -- issued an eponymous 1987 solo cassette on the fledgeling TeenBeat tag, Ween released their own debut tape, The Crucial Squeegie Lip, on their own Bird O' Pray depression. After a match of 1988 self-releases, highborn Axis: Bold as Boognish and The Live Brain Wedgie/WAD LP, Ween signed to the Minneapolis-based independent label Twin/Tone, which in 1990 issued the bivalent album GodWeenSatan: The Oneness, a sprawl, frequently brilliant discharge which careened from the precipitately hardcore rush of the opening "You Fucked Up" to the helium pop of "Don't Laugh I Love You" to the Prince-Xeroxed funk of "L.M.L.Y.P."


A move to the Shimmy Disc tag followed prior to the release of 1991's The Pod, another masterpiece of dementedness recorded on four-track under the influence of inhaled Scotchgard; darker and more deranged than its predecessor, The Pod expanded the Ween palette to include Beatlesque crop up (the sublime "Porc Roll Egg and Cheese"), eccentric family line ("Oh My Dear [Falling in Love]"), and mystic hard rock ("Captain Fantasy"). Against all odds, the record south Korean won the Weens a deal with major tag Elektra; against even greater odds, the leap to the big leagues did nada to alter the duo's mentality. 1992's Pure Guava, their Elektra debut, was their most consistently uncanny and rattling picnic to date. Highlighted by the disturbingly infectious single "Crusade th' Little Daisies" (a Top Ten score in Australia), Pure Guava establish the group as snarky as always on self-explanatory workouts wish "Reggaejunkiejew," "Hey Fat Boy (Son of a bitch)," and "Flies on My Dick"; "Springtheme" mocked love songs at their queasiest; spell the climactic "Don't Get 2 Close (2 My Fantasy)" distilled the grandiloquent excesses of Queen's "Bohemian Rhapsody" and Queensrÿche's "Silent Lucidity" into an epic artistry rock portrayal of child molestation.


Consecrate to the former comedic thespian John Candy, 1994's Chocolate and Cheese -- its title a perfect sum of the duo's blend of R&B and schlock -- upped the ante yet once more. Widening the net to frame rodeo rider songs ("Floater in the Dark"), Philly person ("Freedom of '76"), Afro-Caribbean funk ("Juju Lady"), and Sergio Leone-inspired spaghetti Western epics ("Buenas Tardes Amigo"), Chocolate and Cheese besides featured "Spinal anesthesia Meningitis (Got Me Down)" and "Mister Would You Please Help My Pony," two of the creepiest tales of childhood trauma always committed to vinyl. Having interpreted their anything-goes aesthetic to its ordered extreme, Ween took a sharp leftfield grow for 1996's 12 Golden Country Greats, a ten-track concept album recorded in Nashville with Music City session luminaries including the Jordanaires, Bobby Ogdin, Russ Hicks, Hargus "Pig bed" Robbins, and Charlie McCoy. While the song titles alone -- among them "Nipponese Cowboy," "Mister Richard Smoker," and "Help Me Scrape the Mucus Off My Brain" -- served poster that the group's lyrical attitude had not neutered one smidgin, the music was unco remindful of Nashville's golden era, and performed with accomplishment and fondness.


A spell with Ogdin and a backing unit of measurement dubbed the Shit Creek Boys (which included steel guitar player Stuart Basore, guitarist Danny Parks, twiddler Hank Singer, and bassist Matt Kohut) followed prior to the acquittance of 1997's The Mollusk, a concise, mock-progressive semi-concept album that proven to be i of Ween's strongest efforts. The follow-up was a double-disc concert digest, Paintin' the Town Brown: Ween Live '90-'98, issued in 1999. In the give of 2000, the duo resurfaced with White Pepper, their low gear new studio effort in three days; it peaked at 121 on the Billboard charts, their highest placing to date.


In 2001, Ween began cathartic a serial publication of live albums through their Internet-based independent label, Chocodog. The low gear of these, Live in Toronto Canada, captured a show with the Shit Creek Boys. Around this time, the ring and Elektra parted slipway, and Ween was without a criminal record label as they worked on their eighth studio apartment album. After a wait of 2 years -- during which time they released some other live album, the triple-disc Live at Stubb's -- they signed with Sanctuary Records in 2003, cathartic Quebec City in August of that class. It was the low gear Ween album to crack the Top C, peaking at 81. A few months later on the vent of Quebec, some other independent springy record album followed (Live by Request), and then in the springiness of 2004 they released Live in Chicago, a combination DVD/CD fructify, on Sanctuary, drift back into the studio to process on their ninth studio album. The resulting Cucaracha arrived in October 2007 and was prefaced by the Friends EP in the beginning in the yr.





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Pamela Anderson Donates Car To Charity

Pamela Anderson is donating her prized car, a 2000 Dodge Viper, to PETA, so the animal rights group can sell the custom-made vehicle at an upcoming Hollywood memorabilia auction.

The former 'Baywatch' star, who customized the car herself, will personally oversee the sale of the vehicle, she told The Associated Press.

"I'm a terrible driver," she said, "and it's just not a good idea for me to have a Viper."

Anderson, 40, who has been involved with PETA (People for the Ethical Treatment of Animals) for 15 years, says of the group, "They're kind of my ethical advisers. With them, I see actual results."

The car will be among several celebrity items up for sale at Julien's Auctions' Summer Entertainment Sale of Hollywood memorabilia, to be held June 21 and 22 at the Planet Hollywood Resort & Casino in Las Vegas.

Other offerings include Alfred Hitchcock's driver's license, personal photos of Marilyn Monroe and Sammy Davis Jr, and an original 'Ben Hur' script signed by Charlton Heston. The sale will be broadcast live on Auction Network. 

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Photo courtesy of Fox. Photo taken by Jeff Vespa.